topic Had the same problem… in Product Forum https://community.blueprism.com/t5/Product-Forum/Mapiex-Error-Failed-to-access-Message-Store/m-p/46712#M2631 Had the same problem. Disabling cached exchange mode fixed it for me.   Tue, 09 Oct 2018 19:50:00 GMT ChristianJuhl 2018-10-09T19:50:00Z Mapiex Error - Failed to access Message Store https://community.blueprism.com/t5/Product-Forum/Mapiex-Error-Failed-to-access-Message-Store/m-p/46709#M2628 I'm using the BluePrism Mapiex object to send and get mails, but I'm having the following issue: ERROR: System Exception : Error while sending e-mail:Failure in Send Mail function of Blue Prism Extended MAPI Automation. Failed to access message store I've already tried to open Outlook Client before, open as safe mode and sometimes works, sometimes don't. Scenario: Outlook 2016 Windows 10 Enterprise Blue Prism 5.0.30.0 Mapiex 1.1.15 Exchange E-mail accounts Fri, 08 Jun 2018 23:56:00 GMT https://community.blueprism.com/t5/Product-Forum/Mapiex-Error-Failed-to-access-Message-Store/m-p/46709#M2628 Anonymous 2018-06-08T23:56:00Z I have the same issue, how… https://community.blueprism.com/t5/Product-Forum/Mapiex-Error-Failed-to-access-Message-Store/m-p/46710#M2629 I have the same issue, how do you resolve it? Tue, 14 Aug 2018 02:05:00 GMT https://community.blueprism.com/t5/Product-Forum/Mapiex-Error-Failed-to-access-Message-Store/m-p/46710#M2629 MAYRAALVAREZ 2018-08-14T02:05:00Z Also encountered the same… https://community.blueprism.com/t5/Product-Forum/Mapiex-Error-Failed-to-access-Message-Store/m-p/46711#M2630 Also encountered the same issue. I read from a post in linkedin, logging out and logging in to Outlook may resolved the issue but  unfortunately it did not work for me. Apparently, the profile I was using was not active. Got it resolved by checking the outlook profiles and indicating a correct (active) profile in BP. To check available profiles: Go to Control Panel> Type ""Mail"" in Search box > Mai (32-bit) > Show Profiles Hope this helps.       Tue, 02 Oct 2018 12:19:00 GMT https://community.blueprism.com/t5/Product-Forum/Mapiex-Error-Failed-to-access-Message-Store/m-p/46711#M2630 TristanEco 2018-10-02T12:19:00Z Had the same problem… https://community.blueprism.com/t5/Product-Forum/Mapiex-Error-Failed-to-access-Message-Store/m-p/46712#M2631 Had the same problem. Disabling cached exchange mode fixed it for me.   Tue, 09 Oct 2018 19:50:00 GMT https://community.blueprism.com/t5/Product-Forum/Mapiex-Error-Failed-to-access-Message-Store/m-p/46712#M2631 ChristianJuhl 2018-10-09T19:50:00Z