Tuesday
Each weekend, after windows update- either Runtime goes down on missing state or if the Login agent service keeps running. The process stages goes on missing state. then have to release it manually and delays execution.
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Thursday
mostly this will happen due to database size issue and those bot memory issue and App server load issue.
here our COE team always do App Server reboot for this issue
Thursday
As a side note, I would advise against unobserved and untested windows updates happening overnight to virtual machines that run business critical automations overnight. Your service model should include planned and tested windows updates on the automation VM estate.