IFRAME is used to embed contents from another source. So, one of the ways would be to retrieve the source url from the IFRAME attribute and use it to open the source url and then spy/use the elements on the target page.
Per the guidlelines document, it is best to recover in the Process, rather than the object. Have a retry counter in the process (say 5), and have a delay (say 10 seconds) in the object action 'Attach'. Whenever an exception related to 'Not running' a...