Hi Aditya,
There's not a way to do this out-of-the-box in Blue Prism, but it should be possible to create a VBO that utilizes a code stage that can check if a file is already open.
This StackOverflow article has some VB code suggestions that may work for this.
Alternately, if others here have suggestions for how to perform this type of check with the existing SharePoint VBO(s) on the DX and/or functions within a custom VBO, hopefully they can share them in this thread as well.
------------------------------
Steve Boggs
Senior Product Support Engineer
Blue Prism
Austin, TX
------------------------------