I would need to see a screenshot of what you're referring to, but from the way you describe it, you'll probably want to find a piece of text or an image that you can use as an anchor and then make the field you're referring to dependent on that anchor's location. So, in short, yes you can set a region's location by Coordinates. But it is always best to make those coordinates based on finding some other element that is not based on coordinates first.
The Surface Automation guide (https://portal.blueprism.com/documents/standard?title=surface+automation&category=All〈=1382&=Apply) has good examples of how to do this. If you haven't already gone through the Surface Automation training (documents/exercises), then you should go ahead and do that. SA is a lot easier once you see how Blue Prism intends for you to use it.
Dave Morris, 3Ci at Southern Company