Hi Rob,
You may have seen this Support Center article already, but I'm posting it here for reference: https://help.blueprism.com/1149741322
Did you check the Win Event logs as well, in case it provides any more detail?
And since you have other Resource PCs, are the firewall settings the same between the ones that work and this one that doesn't?
Respectfully,
Dave
Dave Morris
3Ci at Southern Company
Atlanta, GA