Hi John,
It sounds like when you close the PDF and reopen it, you may not attach the document to the spying mechanism anymore. That's why it is giving you an error not unable to find the region identified. You want to make sure you save the spying elements before you exist the surface automation. You could set the position to "anywhere", which will force Blue Prism to hunt around the entire window for your element.
Hope this help.
Thanks,
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In Joe Khor
Sr. Product Consultant
Blue Prism
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In Joe Khor
Sr. Product Consultant
Blue Prism