If you do only the click in region mode, it will work.
Some websites & webapps, especially heavily JS backed web-sites/apps sometimes don't 'react' on 'HTML-clicks'
Sometimes an click in AA (active accessebility) mode works, sometimes only Surface Automation (region mode) works.
A good practice is also to check in your process of the outcome of the click is reached (e.g. with an inteligent wait stage) so if it goes wrong, in your logs you can exactly see what goes wrong where.